Melanocortin 4 receptor is a transcriptional target of nescient helix-loop-helix-2
نویسندگان
چکیده
منابع مشابه
Prokineticin 2 is a target gene of proneural basic helix-loop-helix factors for olfactory bulb neurogenesis.
Prokineticin 2, a cysteine-rich secreted protein, regulates diverse biological functions including the neurogenesis of olfactory bulb. Here we show that the PK2 gene is a functional target gene of proneural basic helix-loop-helix (bHLH) factors. Neurogenin 1 and MASH1 activate PK2 transcription by binding to E-box motifs on the PK2 promoter with the same set of E-boxes critical for another pair...
متن کاملID helix-loop-helix proteins
The helix-loop-helix (HLH) family of transcription factors comprises >200 members, which have been identified in organisms from yeast to man (reviewed in Littlewood and Evan, 1995; Massari and Murre, 2000). In metazoa, HLH proteins function in the coordinate regulation of gene expression, orchestrating cell cycle control, cell lineage commitment and cell differentiation. An essential role has b...
متن کاملStructure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition.
Helix-loop-helix (HLH) family transcription factors regulate numerous developmental and homeostatic processes. Dominant-negative HLH (dnHLH) proteins lack DNA-binding ability and capture basic HLH (bHLH) transcription factors to inhibit cellular differentiation and enhance cell proliferation and motility, thus participating in patho-physiological processes. We report the first structure of a fr...
متن کاملThe basic helix-loop-helix transcription factor Mist1 functions as a transcriptional repressor of myoD.
A good model system to examine aspects of positive and negative transcriptional regulation is the muscle-specific regulatory factor, MyoD, which is a basic helix-loop-helix (bHLH) transcription factor. Although MyoD has the ability to induce skeletal muscle terminal differentiation in a variety of non-muscle cell types, MyoD activity itself is highly regulated through protein-protein interactio...
متن کاملHelix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers.
A family of nuclear proteins, designated SL3-3 enhancer factors 2 (SEF2), were found to interact with an Ephrussi box-like motif within the glucocorticoid response element in the enhancer of the murine leukemia virus SL3-3. Mutation of the DNA sequence decreased the basal enhancer activity in various cell lines. The important nucleotides for binding of SEF2 are conserved in most type C retrovir...
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ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2011
ISSN: 0303-7207
DOI: 10.1016/j.mce.2011.05.022